US, Russian, Japanese astronauts return from ISS
DNA research in space
Rookie Rubins' participation in the mission generated particular excitement after NASA announced plans for the career scientist to sequence DNA aboard the ISSin a world first.
In August Rubins successfully sequenced samples of mouse, virus and bacteria DNA using a device called MinION while Earth-based researchers simultaneously sequenced identical samples.
NASA said the biomolecule sequencer investigation could help to identify potentially dangerous microbes aboard the ISS and diagnose illnesses in space.
Rubins was also the first woman aboard the ISS since Italian Samantha Cristoforetti returned to Earth with the record for the longest single spaceflight by a woman (199 days) in June last year.
Fellow American Peggy Whitson, 56, will blast off to join an all-male crew at the lab with French astronaut Thomas Pesquet and Russian cosmonaut Oleg Novitskiy from the Baikonur cosmodrome November 17.
The blastoff was delayed by 48 hours as Russian space officials sought better docking conditions.
Whitson is NASA's most experienced female astronaut and will command the ISSfor the second time after becoming the first female commander of the station on her second space mission back in 2007.
Pesquet, 38, is a first time-flyer and the first French national to be sent to the ISSby the European Space Agency since 2008.
He said at a pre-flight press conference on Wednesday that he feared he would be "a pain for everybody" as he plans to bring his saxophone with him into space.
NASA's Shane Kimbrough and Andrei Borisenko and Sergei Ryzhikov of Roscosmos are currently aboard the orbital lab having blasted off from the Cosmodrome in another delayed launch on October 19.
Technical mishaps have complicated plans to extend the periods during which theISS is fully staffed with six astronauts.
The space laboratory has been orbiting Earth at about 28,000 kilometres per hour (17,000 miles per hour) since 1998.
Space travel has been one of the few areas of international cooperation between Russia and the West that has not been wrecked by the Ukraine crisis.
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